Where to buy pleconaril

Insights into the genetic basis for natural phenotypic resistance of human rhinoviruses to pleconaril. Relationship of pleconaril susceptibility and clinical outcomes in treatment of common colds caused by rhinoviruses. Antimicrob Agents Chemother. Efficacy and safety of oral pleconaril for treatment of colds due to picornaviruses in adults: results of 2 double-blind, randomized, placebo-controlled trials.

Clin Infect Dis. Enteroviral meningitis: natural history and outcome of pleconaril therapy. Double blind placebo-controlled trial of pleconaril in infants with enterovirus meningitis.

Pediatr Infect Dis J. Pleconaril-resistant chronic parechovirus-associated enteropathy in agammaglobulinaemia. Oral pleconaril treatment of picornavirus-associated viral respiratory illness in adults: efficacy and tolerability in phase II clinical trials. Klin Padiatr. Pleconaril is a small-molecule inhibitor with activity against viruses in the picornaviridae family, including enterovirus and rhinovirus.

Pleconaril binds to a hydrophobic pocket in the major capsid protein and prevents uncoating of the viral RNA genome. In enteroviruses it also prevents the virus from attaching itself to the host cell. Pleconaril is an antiviral drug from viral capsid inhibitor class, manufactured by Schering-Plough and intended for the prevention of acute asthma exacerbations and common cold symptoms in asthmatic patients who have had exposure to picornavirus. It acts by inhibiting viral replication.

The use of pleconaril has not gained approval by the U. Product Name. Citations References and Literature. Benschop KS, et al. Genetic and antigenic structural characterization for resistance of echovirus 11 to pleconaril in an immunocompromised patient.

J Gen Virol. Lacroix C, et al. Virol J. Related Products Related compounds with same targets. Dose Conversion. In vivo Formulation Calculator Clear solution. Calculate Reset. Calculation results:. Be sure to add the solvent s in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving. Molarity Calculator. Molecular Weight.

Molarity Calculator allows you to calculate the Mass of a compound required to prepare a solution of known volume and concentration Volume of solution required to dissolve a compound of known mass to a desired concentration Concentration of a solution resulting from a known mass of compound in a specific volume See Example.

Calculator the dilution required to prepare a stock solution Calculate the dilution required to prepare a stock solution The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. See Example. Infectious viral loads were subsequently quantified by end-point titration. In the presence of ca and pleconaril, heat-inactivation of HRV14 IC wild-type shifted to higher temperatures, suggesting that both compounds stabilize the viral capsid and protect the virus from heat degradation Fig.

Some residual protection was still observed, which is in agreement with the fact that the reverse-engineered pleconaril-resistant HRV strain is only partially resistant to the antiviral activity of the compounds. Effect of ca and pleconaril on heat-inactivation of HRV Sequence alignment of the VP1 residues reported to constitute the hydrophobic pocket within the capsid were constructed with the use of CLC sequence viewer Qiagen.

The full alignment of HRV-A VP1 proteins revealed an alanine on position HRV02, FG loop for the naturally compound-resistant strains, while a serine or threonine was detected for the strains against which moderate activity was observed, and a proline in the most susceptible strains Fig. Alignment was constructed with CLC sequence viewer Qiagen. The cross-resistance and thermostabilizing studies indicate that the antiviral effect of ca is due to a pleconaril-like mechanism of action, i.

The Plants-proposed [ 14 ] ca docking pose well resembled the binding mode that was reported for pleconaril with the two derivatives sharing many key interactions. Replacing the alanine at the bottom tip of the cleft with the bulkier valine narrowed the binding pocket, which causes a slight shift in binding mode. It should be noted that this shift did not disrupt the key binding interactions that were observed for wild-type HRV14 Additional file 3 : Figure S3.

The modelling results therefore corroborate the biological results i. Residues involved in direct interactions are depicted as white sticks. Additional docking studies were carried out with the VP1 of HRV42, a virus serotype featuring the YF and VL mutations that have been associated with resistance to pleconaril [ 15 ].

It was reported that the replacement of valine with the bulkier leucine narrowed the binding cleft with consequent negative steric effects [ 15 ]. On the contrary, the binding mode of ca seemed to be only weakly affected due to the smaller size of the unsubstituted phenyl ring near position , while all other interactions were retained, which is reflected in the anti-HRV42 activity of ca Additional file 4 : Figure S4.

Combating enterovirus replication: state-of-the-art on antiviral research. Biochem Pharmacol. The role of viruses in acute exacerbations of asthma.

J Allergy Clin Immunol. Experimental rhinovirus infection as a human model of chronic obstructive pulmonary disease exacerbation. Senior K. FDA panel rejects common cold treatment. Lancet Infect Dis. PubMed Article Google Scholar. Isoxazoles with antipicornavirus activity. J Med Chem. In vitro activity of pirodavir R , a substituted phenoxy-pyridazinamine with broad-spectrum antipicornaviral activity.

Antimicrob Agents Chemother. Safety and efficacy of intranasal pirodavir R in experimental rhinovirus infection. Intranasal pirodavir R77, treatment of rhinovirus colds.

Study of the biological activity of novel synthetic compounds with antiviral properties against human rhinoviruses. Synthesis of new compounds with promising antiviral properties against group A and B Human Rhinoviruses. Bioorg Med Chem. A novel benzonitrile analogue inhibits rhinovirus replication.

J Antimicrob Chemother. Structural and virological studies of the stages of virus replication that are affected by antirhinovirus compounds. J Virol. J Chem Inf Model. VP1 sequencing of all human rhinovirus serotypes: insights into genus phylogeny and susceptibility to antiviral capsid-binding compounds.